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小麦基因编辑与新材料创制组长夏兰琴 - 中国农业科学院作物科学研究所

  

  

姓  名:夏兰琴   性 别: 女
职  称:研究员
联系电话:010-82105804
电子邮箱:xialanqin@caas.cn
个人网页:
课 题 组:小麦基因编辑与新材料创制
 

组长简介:

夏兰琴,女,博士,三级研究员,博士生导师。1984-1988年沈阳农业大学,获学士学位。1992-1995年中国农科院研究生院,获硕士学位。1997-2000年中国农科院生物技术研究所,获得博士学位。同年,分配到中国农科院作物科学研究所工作。2002年和2003年, 在德国慕尼黑大学(Munich University)植物研究所从事博士后研究。2007年8-10月德国植物遗传育种研究所(IPK)高级访问学者。2005年6-12月和2007-2008年分别作为访问学者和RI Research Fellow在英国洛桑实验站(Rothamsted Research)从事农杆菌介导的小麦遗传转化和抗蚜虫基因工程合作研究。2012年10-12月,在加拿大农业部Lethbridge研究中心从事小麦小孢子培养合作研究。2018年入选中国农业科学院‘农科英才’C类领军人才。

研究方向:

农作物基因编辑新技术、新方法及新种质创制;小麦抗蚜虫基因工程。

主要贡献:

近年来主要从事CRISPR/Cas介导的基因组编辑新技术、新方法及其在小麦、水稻重要农艺性状改良中的应用;小麦蚜虫诱导抗性相关基因的分离和鉴定、植物来源的蚜虫报警信息素合成酶基因功能分析、蚜虫RNAi靶标基因的筛选和鉴定及抗蚜虫转基因小麦新种质的创制。已在国内外核心期刊发表相关论文70余篇,其中,第一作者或通讯作者在Nature Biotechnology, Molecular Plant, New Phytologist, Plant Biotechnology Journal, J Exp Bot等刊物发表SCI论文50余篇。申请发明专利30余项,获得授权发明专利20项。参编英文著作Biotechnology of Major Cereals (CAB International) 1部。

获奖成果和荣誉称号:

获国家科技进步一等奖(排名10)和北京市科技进步一等奖各一项(排名12)。2018年入选中国农业科学院‘农科英才’C类领军人才。

发表的主要论文:

1.Shaoya Li, Jingying Li, Yubing He, Meilian Xu, Jiahui Zhang, Wenming Du, Yunde Zhao  and Lanqin Xia*  (2019) Precise gene replacement in rice by RNA transcript-templated homologous recombination. Nature Biotechnology, 37 (4): 445–450 (*Corresponding author)
2.Yongwei Sun, Caroline Sparks, Huw Jones, Mandy Riley, Frédéric Francis, Wenming Du and Lanqin Xia* (2019) Silencing an essential gene involved in infestation and digestion in grain aphid through plant-mediated RNA interference generates aphid-resistant wheat plants. Plant Biotechnology Journal, 17: 852–854 (*Corresponding author)
3.Li JY, Luo JM, Xu ML, Li SY, Zhang JH, Li HY, Yan L, Zhao YD and Xia LQ *. 2019. Plant genome editing using xCas9 with expanded PAM compatibility. J Genetics and Genomics, https://doi.org/10.1016/j.jgg.2019.03.004
4.Li S, Zhang X, Wang W, Guo X, Wu Z, Du W, Zhao Y, Xia LQ*. 2018. Expanding the scope of CRISPR/Cpf1-mediated genome editing in rice. Molecular Plant, 11: 995-998 (*Corresponding author)
5.Li SY, Li JY, Zhang JH, Du WM, Fu JD, Sutar S, Yunde Zhao YD and Xia LQ* (2018). Synthesis-dependent repair of Cpf1-induced double-strand DNA breaks enables targeted gene replacement in rice. J Exp Bot, 69(20): 4715-4721 (*Corresponding author)
6.Li J, Zhang X, Sun Y, Zhang J, Du W, Guo X, Li S, Zhao Y, Xia LQ*. 2018. Efficient allelic replacement in rice by gene editing: a case study of the NRT1.1B gene. Journal of Integrative Plant Biology, 60(7): 536-540 (*Corresponding author)
7.Li, J., Sun, Y., Du, J., Zhao, Y., and Xia, LQ. * (2017). Generation of targeted point mutations in rice by a modified CRISPR/Cas9 system. Molecular Plant, 10: 526-529 (*Corresponding author)
8.Sun, Y., Jiao, G., Liu, Z., Zhang, X., Li, J., Guo, X., Du, W., Du, J., Francis, F., Zhao, Y., and Xia, L.Q*(2017) Generation of high-amylose rice through CRISPR/Cas9-mediated targeted mutagenesis of starch branching enzymes. Front. Plant Sci, 8, 298. (*Corresponding author)
9.Sun Y, Zhang X, Wu C, He Y, Ma Y, Hou H, Guo X, Du W, Zhao Y, Xia L.Q*. (2016). Engineering herbicide-resistant rice plants through CRISPR/Cas9-Mediated homologous recombination of acetolactate synthase. Molecular Plant 9, 628-631. (*Corresponding author)
10.Sun, Y., Li, J., and Xia, LQ*. (2016). Precise genome modification via sequence-specific nucleases-mediated gene targeting for crop improvement. Front. Plant Sci, 7: 1928. (*Corresponding author)
11.Wang, G.P., Yu, X.D., Sun, Y, Jones, H.D., and Xia, L.Q*. (2016). Generation of Marker- and/or Backbone-Free Transgenic Wheat Plants via Agrobacterium-Mediated Transformation. Front Plant Sci, 7:1324. (*Corresponding author)
12.Yu, X.D., Liu, Z.C., Huang, S.L., Chen, Z.Q., Sun, Y., Duan, P.F., Ma, Y.Z., and Xia, L.Q*. (2016). RNAi-mediated plant protection against aphids. Pest Manag. Sci., 72:1090-1098. (*Corresponding author)
13.Yan, T., Chen, H., Sun, Y., Yu, X., and Xia, L. Q* (2016). RNA Interference of the Ecdysone Receptor Genes EcR and USP in Grain Aphid (Sitobion avenae F.)Affects Its Survival and Fecundity upon Feeding on Wheat Plants. International Journal of Molecular Sciences, 17:2098. (*Corresponding author)
14.Yan Zhang, Zhi-Xia Li, Xiu-Dao Yu, Jia Fan, John A. Pickett, Huw D. Jones, Jing-Jiang Zhou, Michael A. Birkett, John Caulfield, Johnathan A. Napier, Guang-Yao Zhao, Xian-Guo Cheng, Yi Shi, Toby JA. Bruce and Lan-Qin Xia*(2015). Molecular characterization of two isoforms of a farnesyl pyrophosphate synthase gene in wheat and their roles in sesquiterpene synthesis and inducible defence against aphid infestation. New Phytologist, 206:1101-1115. (*Corresponding author)
15.Gen-Ping Wang, Xiu-Dao Yu, Jia Fan, Cheng-She Wang, Lan-Qin Xia*(2015). Expressing an (E)-β-Farnesene synthase in the chloroplast of tobacco affects the preference of green peach aphid and its parasitoid. J of Integr Plant Biology, 2015, 57(9):770-782. (*Corresponding author)
16.Dahai Wang, Qi Liu, Xia Li, Yongwei Sun, Hui Wang and Lanqin Xia*. (2015)Double stranded RNA in the biological control of grain aphid (Sitobion avenae F.). Funct Integr Genomics, 15:211-223 (*Corresponding author)
17.Dahai Wang, Qi Liu, Huw D. Jones, Toby Bruce and Lanqin Xia*. 2014. Comparative transcriptomic analyses revealed divergences of two agriculturally important aphid species. BMC Genomics, 15:1023 (*Corresponding author)
18.Xiudao Yu, Genping Wang, Siliang Huang, Youzhi Ma and Lanqin Xia*. 2014. Engineering plants for aphid-resistance: current status and future perspectives. Theor Appl Genet, 127: 2065-2083 (*Corresponding author)
19.Dong-Yao Gao, Zhao-Shi Xu, Yi He, Yong-Wei Sun, You-Zhi Ma and Lan-Qin Xia* 2014. Functional Analyses of an E3 ligase Gene AIP2 from Wheat (Triticum aestivum L.) in Arabidopsis Revealed Its Roles in Seed Germination and Pre-harvest Sprouting. J of Integr Plant Biology, 56(5): 480-491 (*Corresponding author)
20.Y. Yang, C. L. Zhang, S. X. Liu, Y. Q. Sun, J. Y. Meng, L. Q. Xia*. 2014. Characterization of the rich haplotypes of Viviparous-1A in Chinese wheats and development of a novel sequence tagged site marker for pre-harvest sprouting resistance. Mol Breeding, 33:75-88 (*Corresponding author)
21.H. H. Bi, Y. W. Sun, Y. G. Xiao, L. Q. Xia*. 2014. Characterization of DFR allelic variations and their associations with pre-harvest sprouting resistance in a set of red-grained Chinese wheat germplasm. Euphytica, 195:197-207. (*Corresponding author)

近五年获得授权发明专利(第一发明人)

1.抗草甘膦基因、专用表达载体及其在获得抗草甘膦转基因小麦中的应用,授权号: 201410250631.9
2.用于获得无标记转基因植物的农杆菌专用载体组合物及其应用. 授权号:ZL201410160245.0
3.一种蜕皮激素受体基因EcR dsRNA及其在控制蚜虫危害中的应用。授权号: ZL 201410328241.9
4.一种蚜虫共生菌基因的dsRNA及其在抑制蚜虫生长中的应用. 授权号:ZL201410328123.8
5.一种蜕皮激素受体基因USP dsRNA及其在控制蚜虫危害中的应用. 授权号:ZL201410328484.2
6.一种抑制麦蚜腺体蛋白MYS2基因表达的dsRNA及其应用,授权号:ZL201310556579.5
7.一种抑制麦蚜细胞色素C氧化酶VIIc亚基基因表达的dsRNA及其应用,授权号: ZL 201310556607.3
8.dsRNA及其组合在控制蚜虫危害中的应用, 授权号: ZL 201310007173.1
9.两种dsRNA及其组合在控制蚜虫危害中的应用, 授权号: ZL 201310007203.9
10.一种抑制麦蚜唾液腺体分泌多肽基因表达的dsRNA及其应用, 授权号:ZL2013105566636.X
11.dsRNA及其组合在控制蚜虫危害中的应用, 授权号:ZL201310525143.X
12.一种与倍半萜合成相关的蛋白及其编码基因与应用,授权号:ZL201210258647.5
13.一种细胞色素P450基因dsRNA及其在抑制蚜虫生长中的应用, 授权号:ZL201210205601.7
14.一种用于获得无标记转基因植物的农杆菌转化载体组合物及其应用,授权号: ZL201410160278.5
15.一种抑制麦蚜丝氨酸蛋白酶I基因表达的dsRNA及其应用,授权号: ZL 201310556640.6
16.一种细胞色素P450基因dsRNA及其在抑制蚜虫生长中的应用, 授权号:ZL201210205601.7


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